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Vol. 72 (2014) No. 8 p. 940-941



Review de Debut

The development of synthetic method of nitrile without metal cyanide is attracting much attention in synthetic organic chemistry because classical cyanation normally requires toxic metal cyanides and careful handling to prevent the generation of HCN gas. Recently, direct nitrogenation of hydrocarbons has been accomplished as a new approach to synthesize nitriles without metal cyanide. These approaches enable the straightforward utilization of hydrocarbons in organic synthesis. This short review focuses on the direct transformation of methyl arenes, alkynes, and alkenes by using appropriate oxidant and nitrogen sources.

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