An electrophilic halogen is known to behave a halogen bonding donor for Lewis base or anion to interact through a non-covalent bonding both in solid state and in solution. Halogen bonding shows strong interaction with high directionality as well as hydrogen bonding. Lergons reported DABCO·(C8F17I)2 is a recyclable catalyst for Morita-Baylis-Hillman reaction. Huber developed a neutral multidentate halogen bond donor in analogy to anion-binding thiourea organocatalyst. Although there are a few reports employing halogen bonding for organic reactions, the halogen bonding will be a key tool for the design and development of novel catalysts and reactions.
2014 社団法人 有機合成化学協会