Journal of Synthetic Organic Chemistry, Japan
Online ISSN : 1883-6526
Print ISSN : 0037-9980
Accounts
Enantioselective Reaction Using Palladium Pincer Complexes with C2-Symmetric Chiral Bis(imidazoline)s
Shuichi Nakamura
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JOURNALS OPEN ACCESS

2015 Volume 73 Issue 11 Pages 1062-1071

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Abstract

The development of novel chiral catalysts is one of the most challenging areas in organic chemistry. This account summarizes our recent studies on chiral bis(imidazoline)-palladium pincer type catalysts (phebim-Pd). The catalysts can be used in the enantioselective reaction of a wide variety of nitrile compounds with imines giving products in high yields with good stereoselectivities. This process offers a simple and efficient route for the synthesis of functionalized β-aminonitriles and their derivatives. We also examine the enantioselective allylation of ketimines derived from isatins using chiral phebim-Pd complexes to afford products in high yields with good enantioselectivities.

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© 2015 The Society of Synthetic Organic Chemistry, Japan
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