2015 Volume 73 Issue 11 Pages 1092-1098
Pyrrole imidazole alkaloids (PIAs) are a huge, structurally diverse family of compounds that are biosynthetically derived from oroidin and its dimer or tetramer. Many PIAs show significant biological activities, including antitumor, immunosuppressive, and adrenoceptor-related activities. Because of the structural diversity and biological activities, there is considerable synthetic interest in PIAs. In this review, we describe our approaches to the synthesis of representative oroidin monomer-type PIAs, (+)-dibromophakellin (2), (+)-dibromophakellstatin (3) and (+)-cylindradine A (53).