Journal of Synthetic Organic Chemistry, Japan
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
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Synthetic Studies of Oroidin-derived Pyrrole-imidazole Alkaloids
Makoto IwataYuko KamijohKazuo Nagasawa
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2015 Volume 73 Issue 11 Pages 1092-1098

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Abstract

Pyrrole imidazole alkaloids (PIAs) are a huge, structurally diverse family of compounds that are biosynthetically derived from oroidin and its dimer or tetramer. Many PIAs show significant biological activities, including antitumor, immunosuppressive, and adrenoceptor-related activities. Because of the structural diversity and biological activities, there is considerable synthetic interest in PIAs. In this review, we describe our approaches to the synthesis of representative oroidin monomer-type PIAs, (+)-dibromophakellin (2), (+)-dibromophakellstatin (3) and (+)-cylindradine A (53).

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© 2015 The Society of Synthetic Organic Chemistry, Japan
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