有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
Review de Debut
Kinetic Target Guided Synthesisを用いた創薬研究
松丸 尊紀
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ジャーナル オープンアクセス

2015 年 73 巻 12 号 p. 1245-1246

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One of the modern medicinal chemistry methods is kinetic target-guided synthesis, where fragment molecules are interacted with a target protein and those in close proximity on the protein spontaneously cross-link by forming a covalent bond. The reactions, which is applicable to the kinetic target-guided synthesis proceed in water and are required no additional reagent. Here, several examples of kinetic target-guided synthesis are described.

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© 2015 社団法人 有機合成化学協会
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