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有機合成化学協会誌
Vol. 73 (2015) No. 12 p. 1245-1246

記事言語:

http://doi.org/10.5059/yukigoseikyokaishi.73.1245

Review de Debut

One of the modern medicinal chemistry methods is kinetic target-guided synthesis, where fragment molecules are interacted with a target protein and those in close proximity on the protein spontaneously cross-link by forming a covalent bond. The reactions, which is applicable to the kinetic target-guided synthesis proceed in water and are required no additional reagent. Here, several examples of kinetic target-guided synthesis are described.

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