有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
総説および総合論文
イオン対の活用に基づく新奇なキラル配位子の創製と応用
大松 亨介大井 貴史
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2015 年 73 巻 2 号 p. 140-150

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A new strategy for the design of a chiral ligand for asymmetric transition-metal catalysis has been developed. Our strategy is based on the development of achiral cationic ammonium-phosphine hybrid ligands paired with readily available chiral anions. These ion-paired chiral ligands impart a remarkable stereocontrolling ability to their palladium complexes, which catalyze highly enantioselective allylic alkylations of prochiral carbon nucleophiles. Moreover, the exploitation of ion-paired chiral ligands in combinatorial screening has enabled the rapid identification of the optimal ligand for the palladium-catalyzed new asymmetric allylation reaction. We also developed a highly enantio- and diastereoselective [3+2] annulation reaction of 5-vinyloxazolidinones and activated trisubstituted alkenes catalyzed by a palladium complex bearing a different type of ion-paired ligand, which allows for the single-step construction of three contiguous stereocenters, including vicinal all-carbon quaternary stereocenters.

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