有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
Review de Debut
環状二量化核酸とその類縁体の合成と機能
藤野 智子
著者情報
ジャーナル オープンアクセス

2015 年 73 巻 3 号 p. 278-279

詳細
抄録

Being universal second messengers in bacteria, cyclic dinucleotides (CDN) such as cyclic dimeric guanosine 3’,5’-monophosphate (c-di-GMP) and cyclic dimeric adenosine 3’,5’-monophosphate (c-di-AMP) are important multi-functional compounds that regulate a diverse range of processes in bacteria. After the discovery of c-di-GMP as a trigger for an innate immune response in mammalian host cells, CDN have been of topical interest as vaccine adjuvants and immunotherapeutics. This review highlights the innovative discovery backed up by the achievement of efficient CDN synthesis and the CDN analogues for the future therapeutics.

著者関連情報
© 2015 社団法人 有機合成化学協会
前の記事 次の記事
feedback
Top