Catalytic asymmetric reaction is important for the syntheses of optically active medicines and bioactive natural products, because chiral catalysts enable acceleration of reaction and chiral amplification at the same time. Recently, the asymmetric reaction systems based on stimuli-responsive supramolecular catalyst are drawing attention. Such catalysts realize switchability of catalytic properties to control reaction rate and selectivity. This short review focuses on the asymmetric reactons using chirality-switchable catalysts whose structures are dynamically changed by external stimuli such as light, temperature, solvent, and pH.
2015 社団法人 有機合成化学協会