2015 年 73 巻 5 号 p. 483-489
Heck carbonylation reaction is useful for obtaining various carbonyl-containing compounds. Since it usually requires a high pressure of toxic carbon monoxide and reaction is highly exothermic, it needs to take strict process management and safety planning. The use of a flow reactor in place of a large batch plant is expected to reduce not only the size of the apparatus, but the manufacturing costs. Furthermore, the easier control of the reaction under flow conditions could lead to a significant improvement of operational safety in manufacturing process. As a result of extensive studies of Heck carbonylation reaction with a flow reactor, we found that the reaction proceeded with a higher conversion rate under lower temperature and lower pressure conditions compared with the reaction using a batch autoclave reactor. These results would demonstrate that the flow Heck carbonylation reaction is favorable for environmental protection and safer manufacturing. In this paper, we introduce the applicability of a flow reactor to Heck carbonylation reaction and its mass production.