フローリアクターの現状と新規カラムリアクターの開発

抄録

Flow reactor is a powerful tool to synthesize functional compounds at high yield rapidly and continuously. Many types of flow reactors have been developed all over the world so far. Micro reactors using micro-channels or capillary tubes can provide specific selectivity and high yield of the product, due to rapid mixing and thermal exchange in the limited space of micrometers. In addition of such physical effects of the micro reactor, catalyst-combined micro reactors chemically enhance the reaction efficiency and selectivity. Especially, micro reactors with Pd catalysts are widely applied to Pd-mediated flow reactions like hydrogenation, Heck reaction, Suzuki-Miyaura coupling, and so on.  In order to achieve high throughput of flow reactor, Pd-immobilized epoxy monolith have been successfully prepared as the column reactor with high surface area and cavity volume. We also demonstrate fabrication of the Pd-immobilized epoxy monolith and actual examples of flow Heck reaction and Suzuki-Miyaura coupling using this column reactor.