Organofluorine compounds are utilized for pharmaceuticals, agrochemicals, materials, and polymers. On the other hand, they play significant roles in organic synthesis, such as solvents, additives, and catalysts. Recently, it is reported that fluorine atoms can stabilize the conformers of organic molecules and even change the parent compounds’ conformations by stereoelectronic effects. Therefore directing groups or catalysts in regio- or enantioselective reactions have been improved by fluorine atoms incorporated in the molecular designs.
2015 社団法人 有機合成化学協会