有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
Review de Debut
生体内マイケル付加反応を作用機序とした医薬品の開発
市丸 嘉
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ジャーナル オープンアクセス

74 巻 (2016) 10 号 p. 993-994

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Recently, the development of selective and powerful inhibitors for enzymes and receptors by structural basis chemical biology is desired. The development has been made successfully by addition of potential to form covalent-linkage with the target-protein to affinity component. Michael acceptors are a powerful and hopeful function to introduce a potential of the covalent-linkage formation to the anticancer agents. This short review describes several recent examples utilizing the covalent-linkage based on the Michael addition reaction in vivo and a possibility of reversible control of the adduct formation.

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© 2016 社団法人 有機合成化学協会
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