革新的戦略「Two-Phase Synthesis」の概念によるホルボールの19ステップ全合成

抄録

Phorbol, a diterpene isolated in 1934 from hydrolysis products of croton oil, exhibits immunoregulatory, antiviral, and anticancer activities, and has a highly oxygenated tigliane skeleton that is too difficult to synthesize. In past studies, Wender and Cha groups reported the total synthesis of phorbol, but the syntheses require many steps (40∼52 steps). In 2016, Baran group achieved the enantioselective total synthesis of (+)-phorbol in only 19 steps from commercially available (+)-3-carene by using a concept of innovative strategy “two-phase terpene synthesis”.