有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
Review de Debut
革新的戦略「Two-Phase Synthesis」の概念によるホルボールの19ステップ全合成
西川 慶祐
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2017 年 75 巻 3 号 p. 257-258

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Phorbol, a diterpene isolated in 1934 from hydrolysis products of croton oil, exhibits immunoregulatory, antiviral, and anticancer activities, and has a highly oxygenated tigliane skeleton that is too difficult to synthesize. In past studies, Wender and Cha groups reported the total synthesis of phorbol, but the syntheses require many steps (40∼52 steps). In 2016, Baran group achieved the enantioselective total synthesis of (+)-phorbol in only 19 steps from commercially available (+)-3-carene by using a concept of innovative strategy “two-phase terpene synthesis”.

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