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有機合成化学協会誌
Vol. 75 (2017) No. 3 p. 257-258

記事言語:

http://doi.org/10.5059/yukigoseikyokaishi.75.257

Review de Debut

Phorbol, a diterpene isolated in 1934 from hydrolysis products of croton oil, exhibits immunoregulatory, antiviral, and anticancer activities, and has a highly oxygenated tigliane skeleton that is too difficult to synthesize. In past studies, Wender and Cha groups reported the total synthesis of phorbol, but the syntheses require many steps (40∼52 steps). In 2016, Baran group achieved the enantioselective total synthesis of (+)-phorbol in only 19 steps from commercially available (+)-3-carene by using a concept of innovative strategy “two-phase terpene synthesis”.

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