有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
Review de Debut
インドールのC7位選択的C-H官能基化
山口 深雪
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ジャーナル オープンアクセス

75 巻 (2017) 6 号 p. 671-672

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The indole flamework is one of the ubiquitous heterocycles in natural products and pharmaceuticals. Thus, various methods have been developed to afford functionalized indoles. Recently, direct functionalization of indoles at the C7 position has been emerged. Introduction of directing groups such as hydrosilyl, phosphinoyl, and pivaloyl group at the N1 position enables site-selective functionalization via coordination to metal catalysts. In these cases, bulkiness of the directing group is found to be crucial for high reactivity and C7-selectivity.

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