セレンの特性を生かしたペプチド化学の新展開

抄録

Native chemical ligation (NCL), featuring the use of N-terminal cysteinyl peptides and peptide thioesters, is among the most widely used methods to chemoselectively assemble unprotected peptides. To expand the applicability of the NCL-based assembly, ligation techniques using N-terminal selenocysteinyl peptides and/or peptide selenoesters have been developed. This review describes the recent applications of the selenium-driven peptide ligations.