有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
Review de Debut
複雑な炭素骨格の構築法
—リアノドールの全合成—
若森 晋之介
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ジャーナル オープンアクセス

2017 年 75 巻 7 号 p. 770-771

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Ryanodine is a ryanodane diterpene isolated from Ryania speciosa in 1948. This compound has an agonist activity for ryanodine receptor (RyR) as the calcium channel. Moreover, ryanodol is known as the hydrolysis analogue of ryanodine. The structural features of these compounds are a unique complex ring system with highly oxygenated carbon skeleton. Thus, it is important to construct pentacyclic rings and introduce oxygen functions efficiently for the synthesis. In this review, the total syntheses of ryanodol reported by three groups are described.

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