インジウム触媒とヒドロシランを用いた還元的分子変換を中心とする有機合成

抄録

Reductive molecular transformations by indium/hydrosilane catalyst systems are described herein. A catalytic reductive molecular transformation using a hydrosilane is an important synthetic tool, because silicon-based reducing reagents are frequently easy to handle and exhibit high chemoselectivity to each functional group, due to their lower reactivity than that of other reducing agents. In order for a hydrosilane to show the potential ability as a valuable reducing agent in organic synthesis, therefore, the appropriate choice of a catalyst is an imperative and a significant matter. We continue to perform the use of indium catalysts as good promoters for a variety of silane-mediated reductive transformations. In this review, we summarized our recent results for indium-catalyzed or-mediated transformations as the following chapters: (i) simple reductions of functional groups, especially for carboxylic acid derivatives; (ii) reductive alkylations at oxygen-, nitrogen-, halogen-, carbon-, and sulfur-atoms, by using carboxylic acids as alkylation reagents; (iii) applied reactions based on the reductive transformations including cyclization and hydroamination; (iv) other type reactions promoted by indium (III) compounds, such as Knoevenagel condensation and oxidative coupling through Oppenauer oxidation.