2018 年 76 巻 9 号 p. 874-884
Enantioselective vanadium catalysts provide new and powerful tools for the efficient preparation of optically active molecules. Over the past few decades, vanadium catalysts have been utilized in various asymmetric reactions, especially in the field of Lewis acid-based chemistry and redox chemistry. So far, we have developed a dinuclear vanadium(V) complex, which can catalyze the oxidative coupling of 2-naphthols to give the corresponding 1,1’-bi-2-naphthol (BINOL) derivatives through a dual activation mechanism. In the coupling reaction, the two vanadium metals in the chiral complex activate two molecules of 2-naphthol simultaneously achieving a high reaction rate with high enantiocontrol (up to 97% ee). This review will mainly focus on the applications of dinuclear vanadium complexes to oxidative couplings of polycyclic phenols and enantioselective synthesis of oxahelicenes.