有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
総説および総合論文
海洋マクロリド天然物iriomoteolide-2aの全合成:複雑な天然物の構造決定と生物活性評価における全合成の役割
坂本 渓太不破 春彦
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2019 年 77 巻 8 号 p. 831-840

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Marine macrolide natural products are an important source of new chemotherapeutics and their lead compounds. Although in recent years significant advances of NMR instruments have enabled structure determination of natural products at sub-microgram scale, complex macrolides are still challenging targets for structure assignment because many of them contain multiple stereogenic centers along conformationally flexible macrocyclic backbone. Accordingly, total synthesis plays a conclusive role in structure determination of complex macrolides. Furthermore, biological assessment of synthetic material is indispensable for validating the biological activity/potency of natural products. In this paper, we delineate our total synthesis of a marine macrolide iriomoteolide-2a as a case study that demonstrates the significance of total synthesis in natural product chemistry.

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