有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
Review de Debut
芳香族ニトロ化合物の生体分子との共有結合形成反応
渡辺 賢司
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ジャーナル オープンアクセス

2019 年 77 巻 8 号 p. 841-842

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Biological activity and toxicity of nitro compounds in therapeutics have been well studied. However, an attempt for using versatile reactivity of the nitro group for bioconjugation is limited. This review describes i) nitrofuryl compounds that form a covalent bonding with a thiol-containing protein at the adjacent position of the nitro group, and ii) dual reactivity of dinitroimidazoles toward a thiol and an amine, and its application for cyclization of peptides.

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