有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
Review de Debut
多置換インドール骨格を有するNodulisporic Acid類の全合成研究
岡田 卓哉
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ジャーナル オープンアクセス

2019 年 77 巻 8 号 p. 845-848

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Nodulisporic acids A-F, reported by Merck Research Laboratories, show unique biological activity against insects. For the synthesis of Nodulisporic acid F, Smith’s group has developed a new method to construct the indole skeleton and has achieved its first total synthesis. To construct the more advanced Nodulisporic acids, they have developed a new strategy exploiting a palladium-mediated cross-coupling/indole construction tactic based on the Barluenga’s chemistry and have achieved the first total syntheses of Nodulisporic acids D, C, and B via a unified synthetic strategy. In this review, synthetic studies on Nodulisporic acids by Smith’s group are described.

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