フラビン触媒を用いた分子状酸素のみで駆動する酸化的分子変換反応の新展開

抄録

The development of aerobic oxidative transformations is a central, highly rewarding challenge in modern organic chemistry, because those reactions utilize molecular oxygen which is recognized as an ideal oxidant with many advantages such as sustainable abundance, cost-effectiveness, atom-economy, and minimal pollution. Recently, we have developed a novel strategy for the green oxidative transformations by combining iodine catalyst and riboflavin-derived organocatalyst which enables the efficient activation of molecular oxygen. The flavin-iodine-coupled organocatalytic system successfully promotes diverse oxidative transformations requiring molecular oxygen as the only sacrificial reagent, thus provides atom- and step-economical syntheses that fulfill the recent demands of green and sustainable chemistry. In addition, inspired by the photochemical mechanism of a plant blue-light receptor, we have developed a flavin-based photocatalytic system for chemoselective heterocoupling of thiols.