有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
総説および総合論文
生体関連遷移金属錯体を触媒とする脂肪族および芳香族C-H結合の水酸化反応
森本 祐麻伊東 忍
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2022 年 80 巻 5 号 p. 506-516

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Hydroxylation of hydrocarbons is a simple chemical transformation reaction. However, this is not an easier task than it looks in the chemical equations. The reactions generally require harsh (high temperature, high pressure, strongly acidic, or basic) conditions, which induce over oxidation giving a complicated mixture of products. In contrast, living organisms perform such difficult tasks like selective oxidation of methane to methanol and benzene to phenol by employing appropriate oxidizing species generated using earth abundant transition metals (Fe and Cu) in the well-organized reaction centers of metallo-monooxygenases. We have been trying to understand the essence of the chemical functions of such metalloenzymes to construct selective and efficient oxidation reactions of inert aliphatic and aromatic compounds. In this article, our recent accomplishments in this endeavor are summarized together with the backgrounds of the related chemistry.

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