Synthesis of oxy-Functionalized Terpenoids involving the Hexahydroindane Skeleton as a Privileged Structure

Abstract

Hexahydroindane scaffold can be found in the oxy-functionalized terpenoids such as cardiotonic steroids and picrotoxane sesquiterpenoids as a privileged structure for their biological activities. To clarify their novel functions, we have synthesized cardiotonic steroids, a pheromonal steroid, and picrotoxane sesquiterpenoid. In this publication, details of the synthetic studies on these naturally occurring products and related analogues are described, starting from tricyclic lactone as a new chiral building block.

Graphical Abstract