CO₂を原料とする遷移金属触媒を用いた不斉カルボキシ化反応

抄録

Optically active carboxylic acid derivatives are important in the field of medicinal chemistry and pharmaceuticals. Preparation of these chiral carboxylic acids from naturaly abundant CO₂ would be highly valuable, however, the synthetic methodologies have been limited. Transition metal-catalyzed asymmetric synthesis has opened a new window for the direct access to enantio-enriched carboxylic acid derivatives. Herein, recent processes of transition metal-catalyzed asymmetric carboxylation reactions will be discussed.