1962 年 20 巻 11 号 p. 1009-1015
Alkylurea reacts with amine to form a disubstituent. On the other hand, arylurea reacts with aliphatic primary and secondary amine by inter exchange reaction of aryl group and alkyl group and gives free aromatic amine. Therefore, for synthesis of N-alkyl-N'-arylurea by the reaction of a monosubstituted urea and amine, it is necessary to introduce alkyl group at first, then the introduction of aryl group is made. For synthesis of N, N', N'-trisubstituted urea, an introduction of the secondary amine at first does not allow the entrance of subsequent introduction of substituent group.