Abstract
The reaction of di-substituted urea with amines are considered to be the same as in the case of mono-substituted ureas. In this case, aromatic amines are found to be difficult to react with aliphatic di-substituted ureas, but aliphatic amines ase easily reacted with aromatic di-substituted ureas, liberating aromatic amines. The reactions of di-substituted ureas with secondary amines proceed in the case of aromatic di-substituted ureas, but are hindered by increase of aromatic nature of secondary amines.