脂肪族アミンとエポキシプロパン誘導体との反応および反応生成物に関する研究(第1報)
脂肪族アミンとエポキシプロパン誘導体との反応
1964 年 22 巻 7 号 p. 546-552
詳細
1964 年 22 巻 7 号 p. 546-552
The reaction of aliphatic primary and secondary amines with epoxypropane derivatives, such as epichlorohydrin and glycidolsulfonic acid esters in methanol as a solvent at a comparatively low temperature was investigated. At the reaction temperature of 20°c with an amine and epichlorohydrin, only a simple additive reaction such as aminochlorohydrin formation, occurred, sometimes trivial side reaction being followed. With amines and glycidolsulfonic acid. esters, a considerably strong side reaction always occurred. At a low temperature of 2-3°c, a simple additive reaction. (the formation of aminochlorohydrin by ring opening reaction of epoxy group) was sometimes taken. place with amines and glycidolsulfonic acid esters. So, in general there is a suppression of side reaction. It was considered from the tendency of reaction due to the kind of amines that the effect of steric hindrance was large.
