1976 年 34 巻 6 号 p. 369-377
Bisulfite ion adds across the 5, 6-double bond of pyrimidine nucleosides to give the 5, 6-dihydro-6 sulfonate derivatives. Under mild conditions, cytidine-bisulfite adduct is readily hydrolyzed to the corresponding uridine derivative. On the other hand, free radicals, produced when bisulfite ion is auto-oxidized in the presence of oxygen, react with 4-thiouridine, isopentenyladenosine and some other pyrimidine nucleosides. These reactions and their applications to polynucleotides are reviewed.