FAMSOの化学

抄録

During our investigation to search useful derivatives of dimethyl sulfoxide, we encountered a new sulfoxide, methyl methylthiomethyl sulfoxide which was also named formaldehyde dimethyl dithioacetal S-oxide. Now, this compound is designated conveniently as “FAMSO” by abbreviating he latter name.
FAMSO was first synthesized by substitution of chloromethyl methl sulfoxide with a methanethiolate anion and it was later found that this compound could be more easily produced by oxidation of formaldehyde dimethyl dithioacetal with hydrogen peroxide. To date, many papers on organic syntheses using FAMSO have been published and it has appeared to be a versatile reagent for making a variety of organic compounds such as aldehydes, cyclic or acyclic ketones, α-hydroxy aldehydes, α-amino acids, α-keto acids, and α-arylalkanoic acids.
This review will disclose the details of the production of FAMSO and its utilization for organic syntheses.