アンジオテンシン変換酵素阻害剤の合成と薬効

抄録

History of angiotensin-converting enzyme (ACE) inhibitors, their therapeutic role in hypertension and the recent world development trends towards them were reviewed briefly, and our continuous investigations in this field, which led to the discovery of a new potent ACE inhibitor, (2R, 4R) -2- (2-hydroxyphenyl) -3- (3-mercaptopropionyl) -4-thiazolidinecarboxylic acid (SA 446), were disclosed in this paper.