有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
非環状化合物におけるケトンの立体選択的還元と天然物合成への応用
大石 武中田 忠
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1981 年 39 巻 7 号 p. 633-641

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Highly stereocontrolled reduction of α-methyl β-keto esters, 3-hydroxy-2-methyl ketones, and α, β-epoxy ketones with Zn(BH4)2 has been described. In every case, the predominated products were found to be erythro-alcohols. A plausible mechanism to account for these high selectivity is discussed.
Synthetic studies of erythronolide A starting from erythro-3-hydroxy-2-methylpropionates prepared by the reduction of the corresponding β-keto esters with Zn(BH4)2 have also been described.

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