1981 年 39 巻 7 号 p. 633-641
Highly stereocontrolled reduction of α-methyl β-keto esters, 3-hydroxy-2-methyl ketones, and α, β-epoxy ketones with Zn(BH4)2 has been described. In every case, the predominated products were found to be erythro-alcohols. A plausible mechanism to account for these high selectivity is discussed.
Synthetic studies of erythronolide A starting from erythro-3-hydroxy-2-methylpropionates prepared by the reduction of the corresponding β-keto esters with Zn(BH4)2 have also been described.