有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
γ-チオブチロラクトンとアミン類の反応 (第1報)
栗原 博之白井 孝三
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1981 年 39 巻 9 号 p. 860-861

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The reactions of γ-thiobutyrolactone with primary amines (methylamine, butylamine, octylamine, aniline) afforded corresponding 4-mercaptobutanamides in 50%, 76%, 86%, 82% yield, respectively. The reactions with secondary amines (morpholine, pyrrolidine, diethylamine) also afforded corresponding 4-mercaptobutanamides in high yields, respectively. Furthermore, the reaction of two equivalents of 1-thiobutyrolactone with ethylenediamine gave N, N'-ethylenedi-4-mercaptobutanamide in 64 % yield. The mercapto compounds thus obtained were oxidized to the corresponding disulfides by dimethyl sulfoxide.

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