有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
チトクロムP-450をモデルとした反応
宮田 直樹広部 雅昭
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ジャーナル フリー

1983 年 41 巻 9 号 p. 861-869

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Our recent developments related to the cytochrome P-450 model reactions by using iron porphyrin complex are summarized. This article is divided into three sections according to the type of reaction.
The first is the oxidant supported oxidation. Porphinatoiron-oxene complex generated by chloro α, β, γ, δ-tetraphenylporphinato iron (III) (FeIII TPPCl) and 2-iodoso-m-xylene as oxidant smoothly dealkylated several tertiary amines to the corresponding secondary amines.
The second is the oxidation accompanied by the reductive activation of molecular oxygen. Reductive dioxygen activation was achieved by reductant (Na2S2O4, NaBH4 or Zn) -FeIII TPPCl system in protic media and the active intermediate formed by this system oxidized tertiary amines, sulfides and hydrocarbons.
The last is the reductive deoxygenation from several tertiary amine oxides and arene oxides by reduced porphinatoiron (FeII TPP).
Detailed studies on the reaction mechanism are also described.

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