マイクロコンピュータを用いる有機合成のシステム化

抄録

The programmed flow preparation (PFP) system for application of a micro-computer to various aspects of the synthetic research has been developed. The PFP system for oligodeoxyribonucleotide and peptide synthesis consists of the programs and the data base for the synthesis design and the preparation equipments. The preparation apparatus consists of a reactor, an extractor, an evaporator and a liquid chromatograph. In this apparatus, most of the operations in preparation processes are carried out by flow manipulations and can be automatically controlled with a micro-computer.
As a key step for the further development of the PFP system to make it applicable to a wide scope of synthetic research, a micro-computer program for the design of the synthetic routes to complicated molecules has been compiled. This program, written in BASIC, generates the synthetic intermediates retrosynthetically. The application of this program to the synthetic route planning of an alkaloid is also described.