四級炭素不斉構築法の開発と天然物合成への応用

抄録

Recent progress in the construction of chiral quaternary carbon centers by the method of asymmetric carbon-carbon bond forming reaction is described. The article covers, i) asymmetric sythesis by the use of chiral enamines, ii) asymmetric synthesis based on the strategy of fixing conformation of metalloenamines by chelate formation, iii) asymmetric synthesis based on the strategy of optionally controlling the diastereoface selection by an external ligand, iv) asymmetric alkylation by the use of conformationally rigid heterocycles. Asymmetric total syntheses of alkaloid mesembrine, sesquiterpene ivalin, and neolignan megaphone by the application of these methods are also described.