Sesbanimide A and B, potent antitumor alkaloides, isolated from the seeds of the leguminous plant, Sesbania drummondii, constitute unusually attractive targets for total synthesis because of their remarkable antitumor activity and novel structures. This review deals with three independent total syntheses of these novel alkaloids which include our first total synthesis of natural sesbanimide A and B. Concerning formation of the AB-ring system in an optically active form, introduction of the C5-unit into the AB-ring system, and construction of the C-ring system, the synthetic strategies and tactics so far reported are discussed.