含ヘテロ大環状化合物

合成と機能

抄録

Heteromacrocycles have been widely employed because of the unique property of forming stable complexes with a variety of molecules. Recently, new compounds have been designed to construct a rigid complex-forming cavity, such as cavitand, spherand, cryptophane, calixarene, and cucurbitril, whose syntheses and complex-forming properties are briefly discussed in this article. Moreover, the recent developments in utilization of crown ether-type heteromacrocycles have revealed the great ability to enhance selectivity in organic and asymmetric sythesis. Biomimetic chemistry are also developed by the use of the heteromacrocycles as enzyme mimics, realizing biomimetic reactions, such as acyl transfer, hydrogen transfer, and peptide synthesis.