有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
高分子ヘム誘導体の生理機能
土田 英俊
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1988 年 46 巻 9 号 p. 879-892

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The role of reversible oxygen-binding in hemoglobin is appeared since heme is fixed in the higher ordered structure of globin protein. In this review, the newly synthesized heme derivatives, so-called “lipid-heme” embedded in polymerized assembly of phospholipid molecules are explained, which is firstly able to realize oxygen transport in aqueous system comparable to the transporting efficiency of hemoglobin. Also the preliminary results of in vivo tests for aqueous (lipid-heme/polylipid-liposome) systems are added briefly

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