1990 年 48 巻 1 号 p. 29-42
Recently, we have proposed a new designing concept, “Respective Control Concept”, for developing highly efficient chiral bisphosphine ligands. On the basis of our concept, new chiral bisphosphine ligands, BCPM, MOD-BPPM, MOD-DIOP, etc. have been synthesized. Their rhodium complexes have been found to show very high catalytic activity and enantioselectivity in the asymmetric hydrogenations of prochiral carbonyl and olefinic compounds. Practical asymmetric syntheses of useful biologically active compounds have been realized by using these hydrogenations as key reactions.