有機スズ化合物を活用した含窒素複素環への高選択的炭素置換基導入法の開発と含窒素多環式化合物合成への利用

抄録

Highly effective methods for introduction of several kinds of carbon substituents have been developed by means of organotin reagents. Allyl-, alkynyl-, allenyl-, and benzyltin reagents readily react with N-acylated nitrogen heteroaromatics and cyclic imines in a highly chemo- and regioselective manner. Functionalized acylating agents, such as α, β, γ, δ-unsaturated, α, β-unsaturated, and β-halogenated acyl chlorides can be utilized in the reactions and the subsequent intramolecular cyclizations afford nitrogen polycycles related to protoberberine, yohimbane, and indolizidine alkaloids.