1991 年 49 巻 7 号 p. 670-681
Related to antiviral agents, nucleoside antibiotic oxetanocin-A isolated from culture broth of Bacillus megaterium NK 84-0218 served potent biological activities against such virus strains as HIV, HCMV and HSV. Of interest is the novel oxetanoside moiety (four-membered ring sugar) of this antibiotic which would promise developments of new antiviral agents. We describe herein total synthesis of oxetanocin-A as well as new oxetanose chemistries. Recent progress of nucleoside analogues relevant to oxetanocin-A is also included.