有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
オキセタノシンおよび関連化合物の合成とオキセタノースの化学
西山 繁山村 庄亮
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1991 年 49 巻 7 号 p. 670-681

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Related to antiviral agents, nucleoside antibiotic oxetanocin-A isolated from culture broth of Bacillus megaterium NK 84-0218 served potent biological activities against such virus strains as HIV, HCMV and HSV. Of interest is the novel oxetanoside moiety (four-membered ring sugar) of this antibiotic which would promise developments of new antiviral agents. We describe herein total synthesis of oxetanocin-A as well as new oxetanose chemistries. Recent progress of nucleoside analogues relevant to oxetanocin-A is also included.

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