天然物の全合成
アルカロイドからテルペンまで
1993 年 51 巻 2 号 p. 111-127
詳細
1993 年 51 巻 2 号 p. 111-127
This review describes the studies on the total syntheses of the natural products, particularly alkaloids and terpenes, which involves the determination of absolute configurations of emetine, yohimbin and reserpine. It has been attempted in principle that the synthesis should be developed by utilization of the new reactions originated in our own laboratory. The successful syntheses are demonstrated by “one-step synthesis of β-carboline derivatives”, “development of a new synthetic method for 3, 3-disubstituted oxindole derivatives, which method was extended to the synthesis of various indole alkaloids through a common intermediate”, “the total synthesis of strychnos, aspidosperma and schizozygane alkaloids by photo-isomerization of 1-acylindole to 3-acylindolenine”, “the crisscross annulation for syntheses of heterocycles and the natural products” and “bis trimethylsilyl enol ether has been utilized as a 'masked acyl anion'for the synthesis of terpenses and the biologically active cyclic lactones”.
