有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
光学活性ビスオキサゾリニルピリジン (Pybox) ロジウム錯体を用いるケトンの不斉ヒドロシリル化
西山 久雄伊藤 健児
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ジャーナル フリー

1995 年 53 巻 6 号 p. 500-508

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Optically active bis(oxazolinyl)pyridine (Pybox) was developed as a chiral nitrogen ligand for asymmetric hydrosilylation of ketones. Pybox reacted with RhCl3 in ethanol solution to produce a stable RhCl3 (Pybox) complex, which exhibited powerful catalytic activity for the hydrosilylation of ketones with diphenylsilane in the presence of silver tetrafluoroborate. Acetophenone was reduced to 1-phenylethanol in 91% yield and in 94% ee (S). Other simple ketones were reduced to optically active secondary, alcohols in ca. 90% ee on the average. Substituents on the oxazoline rings and on the pyridine ring were also examined to verify the yield and the enantioselectivity due to their steric and electronic effects.

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