有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
海洋性天然毒brevetoxin Bの全合成
佐藤 光伸
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ジャーナル フリー

1997 年 55 巻 8 号 p. 686-696

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Brevetoxin B (1), isolated from dinoflagellate, Gymnodinium breve Davis, has been known as a potent neurotoxin which affect to the current of Na ion of the Na channel.
The total synthesis of this complex compound that includes 11 trans-fused rings and 23 stereocenters was completed under the conduction of Prof. Nicolaou in 0.043% total yield (91% average yields) from 2-deoxy-D-ribose after more than 10 years struggle.
I herein wish to report the strategies and synthetic routes, both failed and successful, toward this destination.

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