1997 年 55 巻 8 号 p. 697-704
HF-κB, HIV-EP1 Sp1, and TBP-E1A are transcriptional proteins involved in the long terminal repeat-directed expression of human immunodeficiency virus. Inhibitory effect of eighteen compounds against NF-κB, HIV-EP1, Sp1, and E1A was studied. The compounds could be classified into six types based on the inhibitory profile. Compounds of class A (ent-2, 11, 12, 13) and B (7, 9) are inhibitory against HIV-EP1. Class B compounds are more potent. Class C (14) compound is a Spl inhibitor. Compounds of D class (1, ent-1, 2) and E (5, 6, 8, 10) are inhibitors of both HIV-EP1 and Sp1. Class E compounds are more potent. NF-κB, HIV-EP1, and Sp1 are all inhibited by class F compounds (3, 4). Zinc complexes of class F compounds inhibit NF-κB without affecting zinc finger proteins. Relevant combination of these inhibitors would allow us to inhibit NF-κB, HIV-EP1, and Sp1 in any combinations.