有用な生理活性物質の全合成と開発
1998 年 56 巻 9 号 p. 714-724
詳細
1998 年 56 巻 9 号 p. 714-724
The total synthesis and development of a variety of bioactive compounds have been accomplished by using unique synthetic strategies and methodologies. Coriolin, rosmarinecine and a side-chain of cephem antibiotics are synthesized through new skeletal rearrangements. Several compounds having naphthopyran and naphthofuran are synthesized by tandem Michael-Dieckmann type reactions. A general method of entry into densely functionalized carbacycles is featured to synthesize a few enzyme inhibitors. The first total synthesis of an anti-HIV, terpestacin, is described and, finally the one-step total synthesis of pyroglutamyl peptidase inhibitor is also discussed.
