Transition-Metal Catalyzed Multi-Component Carbocyclization and Related Reactions of Bifunctional Molecules

Abstract

The selective [2 + 2 + 2] cycloaddition of 1, 6-diynes takes place to give polycyclic 1, 3-cyclohexadienes or arenes using ruthenium or palladium complex catalysts. The rhodium carbonyl cluster is an efficient catalyst for the three-component coupling between carbon monoxide, hydrosilanes, and 1, 6-diynes or 1, 6-enynes. Organotitanium (III) complexes are excellent reagents for the intramolecular carbon-carbon bond formation between the nitrile and carbonyl groups as well as the intramolecular pinacol coupling of dials.