有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
3本鎖形成オリゴヌクレオチドを利用した遺伝子制御とDNAベンド
秋山 泰身
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ジャーナル フリー

1999 年 57 巻 3 号 p. 194-205

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Thermodynamic property of triple helix and the mechanism of inhibition of mRNA transcription by triple helix formation are summarized in this review. I also mention on the artificial DNA bending system in which the antiparallel triple helix motif and synthetic linker consisting of polyether nucleotide units are utilized as the bender. Systematic analysis of this system revealed the anisotropic flexibility of DNA. Thus, DNA seems to be more flexible in minor groove direction as compared to that expected from the classic elastic coil and elastic rod model of duplex DNA.

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