結晶化法光学分割におけるジアステレオマー塩結晶の晶癖変化とその利用-高光学純度1-フェニルエチルアミンの製造

抄録

The process of enantiomeric purity improvement in industrial scale resolution is presented. Enantiomeric purity of 1-phenylethylamine (1) obtained from an industrial resolution with enantiomerically pure mandelic acid (2) as resolving agent, was improved by changing the crystal shape of the intermediate, the less-soluble diastereomeric salt [(R) -1 · (R) -2], through coexistence with a chiral secondary amine derived from substrate 1. Mechanism of the crystal habit modification is discussed and its applications to manufacture are described.