1999 年 57 巻 5 号 p. 458-465
The process of enantiomeric purity improvement in industrial scale resolution is presented. Enantiomeric purity of 1-phenylethylamine (1) obtained from an industrial resolution with enantiomerically pure mandelic acid (2) as resolving agent, was improved by changing the crystal shape of the intermediate, the less-soluble diastereomeric salt [(R) -1 · (R) -2], through coexistence with a chiral secondary amine derived from substrate 1. Mechanism of the crystal habit modification is discussed and its applications to manufacture are described.